Genetic Analysis of Multidrug-resistant Malaria Parasites
Our laboratory studies the molecular basis of antimalarial drug resistance in the human malaria parasite Plasmodium falciparum. One approach is through the analysis of genetic crosses that we implement between multidrug-resistant field isolates and drug-sensitive parasites, using a humanized mouse model to recover recombinant progeny. Whole-genome sequencing, quantitative trait loci analysis and CRISPR/Cas9 editing is used to define the genetic drivers of resistance. We also examine the spread of resistance across endemic regions, based on existing knowledge about resistance pathways.
Areas of Focus