Global OCD International Multisite Study

Obsessive-compulsive disorder (OCD) is a prevalent and disabling disorder, and fewer than half of OCD patients become well with current treatments. This is a transnational research project involving one U.S. site and four sites in other countries—Brazil, India, Netherlands, and South Africa. The goal of the project is to identify brain-based “biosignatures” associated with cognitive and clinical profiles common in individuals with obsessive-compulsive disorder (OCD) that are reproducible across countries and cultures. MRI-based brain imaging measures will be collected using standard protocols across research sites to identify dysfunctional circuits and associate them with clinical and cognitive measures. Identifying brain signatures of measurable behaviors and clinical symptoms will provide robust new treatment targets and help pave the way to precision psychiatry where individual brain signatures can help guide treatment choices. Given variations in culture across the sites, cultural influences on OCD psychopathology may also be identified. Please see our website for additional information:


Blair Simpson


  • Cape Town, South Africa
  • New York, United States
  • Sao Paulo, Brazil
  • Amsterdam, Netherlands
  • Bengaluru, India

Areas of Focus

Mental Health